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Evidence is increasing that every addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This section of the problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people who go through it you should err to the side of caution and allow FDA do its job and demand some study be done so the public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to make money and that they would say anything to keep people on the medications. Researchers found that participants taking this drug to get a year, lost excess weight within one month and have kept the weight off through the 56 weeks from the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of many active ingredient, that might make them more efficient and safer. Combo-pilling will be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular is the fact that as of right now there aren't any long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure and heartbeat, and mustn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high blood pressure level, as well as by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. Acamprosate also functions eliminate the desire to drink by reducing the the cravings for drinking alcohol. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate is not yet obtainable in the United States. While it continues to be widely studied in Europe the complete chemical reason that it works remains unknown. It is belief that it inhibits receptors within the brain which process glutamate, which in place alters the way ones body reacts to alcohol intake. Several of the European research has shown a lot of promise with Acamprosate in this some of the patients had a nearly double success rate for staying sober.